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Come Fan with UsSunday, June 21, 2026

Fantasy football projections, Week 12: Colts vs. Cardinals featuring Andrew Luck, Donald Brown and Michael Floyd

We break down the Week 12 matchup between the Indianapolis Colts and the Arizona Cardinals.

Frederick Breedon

The Week 12 matchup between the Indianapolis Colts and the Arizona Cardinals features a good offense against a good defense. We've got all the fantasy projections for you courtesy of numberFire.

Indianapolis Colts

For whatever reason, the Colts just don't quit no matter what the circumstances. Quarterback Andrew Luck as a gift for being resilient. That said, his ability to win when he's not at his best contradicts his fantasy statistics. Luck scored his fourth rushing touchdown of the season last week, but he's thrown one touchdown and three interceptions in the last two games.

That's why Donald Brown is becoming more of a focal point for the Colts on the ground. Brown carried the ball for 80 yards and a pair of touchdowns last week against the Tennessee Titans. Teammate Trent Richardson has proved ineffective of late and Brown is taking advantage. He'll be in tough against the Cardinals, but he is now a starter in fantasy leagues.

Arizona Cardinals

Carson Palmer has been as solid as you can ask of him in the team's last three games, leading the Cardinals to three straight wins. In all of those games he's thrown at least two touchdowns. He picked the Jacksonville Jaguars apart last week for over 400 yards. What's even more impressive is that Palmer didn't turn the ball over in the game.

If Palmer hopes to continue his hot play, he'll do it throwing to receivers Michael Floyd and Larry Fitzgerald. Both had touchdowns last week but Floyd was particularly impressive. He caught six passes for 193 yards an a touchdown against the Jaguars including a career long 91-yard score in the third quarter. All three players will no doubt have to be at the top of their game to top the Colts in Week 12.

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