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Come Fan with UsSaturday, June 20, 2026

Fantasy football start/sit advice, Week 6: Reggie Wayne

Reggie Wayne has helped make Andrew Luck look like Peyton Manning. Is Wayne going to turn in a big game against the Texans for his fantasy owners?

Michael Hickey

Indianapolis Colts receiver Reggie Wayne hasn't really skipped a beat after his 2013 season ended with a torn ACL. He has 30 receptions on his 45 targets for a team-high 384 receiving yards to go with one touchdown. He's also caught 24 first downs and has caught at least three passes in every game.

Wayne is coming off a 12-target game against a very good Baltimore Ravens defense. Plus, his best game came in Week 4 against the Titans, so he's picking up steam as a popular target for quarterback Andrew Luck. With Luck leading the NFL in passing yards and touchdowns, there are plenty of stats to go around and Wayne should be a top-two option in most weeks.

The Houston Texans have been able to hold Wayne in check and he'll likely see a lot of cornerback Jonathan Joseph.

Fantasy Rankings: QB RB WR TE D/ST

Fantasy impact: If you’re in a PPR league, he almost has to be in your lineup. Wayne is more of a flex in standard leagues just because of the unfriendly matchup and the short week factor.

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