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Come Fan with UsSunday, June 21, 2026

NFL Picks Week 15: Jacksonville Jaguars Vs. Indianapolis Colts

We're entering Week 15 and the the roles have been reversed in the AFC South. The Indianapolis Colts are no longer the front-runner in the division. They've been replaced by the Jacksonville Jaguars. The Colts have won the division for most of this decade but their run may be ending if they can't beat the Jaguars on Sunday.

The Colts, 7-6, trail the Jaguars, 8-5, by one game in the AFC South. It’s looking like just one team will likely enter the playoffs from the AFC South and that’s the division winner. So this is the biggest game in the division this year.

The Colts have struggled lately as they snapped a three-game losing streak last week against the Tennessee Titans. Peyton Manning may be returning to his old self and not the guy who threw 11 interceptions during that three-game losing streak.

Though the Colts haven’t performed like the Colts this year, they’re still the favorite. It’s hard to pick against Indy in this one even if the Jaguars have already beat the Colts. This one is taking place in Indianapolis and I think the Colts should make the division very interesting with a victory.

NFL odds say the Colts are five point favorites and, while I think they’ll win, it’ll be more a field goal game. Check out Big Cat Country and Stampede Blue for more on the game.

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