Skip to main content
Come Fan with UsThursday, June 25, 2026

NFL Odds And Lines Week 10: Giants Vs. 49ers

The New York Giants and San Francisco 49ers face off in one of Week 10’s premier matchups, and 49ers opened as 3.5-point favorites.

LANDOVER, MD - NOVEMBER 6: Alex Smith #11 of the San Francisco 49ers heads off the field after the game against the Washington Redskins at FedEx Field on November 6, 2011 in Landover, Maryland. (Photo by Scott Cunningham/Getty Images)
LANDOVER, MD - NOVEMBER 6: Alex Smith #11 of the San Francisco 49ers heads off the field after the game against the Washington Redskins at FedEx Field on November 6, 2011 in Landover, Maryland. (Photo by Scott Cunningham/Getty Images)
LANDOVER, MD - NOVEMBER 6: Alex Smith #11 of the San Francisco 49ers heads off the field after the game against the Washington Redskins at FedEx Field on November 6, 2011 in Landover, Maryland. (Photo by Scott Cunningham/Getty Images)
Getty Images

Two of the hottest teams in the NFC will show down in Week 10 for a potential preview of a rematch in the playoffs when the New York Giants travel west to visit the San Francisco 49ers. The Giants are coming off a huge comeback victory over the New England Patriots, while the 49ers have the second-best record in football. The folks at Odds Shark believe in the power of home field advantage, though, and have the Niners as 3.5-point favorites.

The Giants have, as is their habit, been maddeningly inconsistent this year. While they're capable of having games like last week's they've also lost to the two-win Seattle Seahawks and almost became the Miami Dolphins' first victory in Week 8. The 49ers, on the other hand, have been the models of consistency, beating teams like the Detroit Lions, the Cincinnati Bengals and the Philadelphia Eagles along their way to a 7-1 record.

Fore more info on these two teams, visit Giants blog Big Blue View, 49ers blog Niners Nation, SB Nation New York and SB Nation Bay Area.

See More:

More in NFL

From SBNationExternal Link
Who wins the AFC South this season?Who wins the AFC South this season?
From SBNationExternal Link
By Mark Schofield
NFL
Brendan Sorsby stuck as NFL announces NO Supplemental Draft in 2026Brendan Sorsby stuck as NFL announces NO Supplemental Draft in 2026
NFL

Another setback for the QB.

By James Dator
NFL
WNFC championship game airing Sunday, June 21st from Ford Center in FriscoWNFC championship game airing Sunday, June 21st from Ford Center in Frisco
NFL

The Women’s National Football Conference Championship will air on ESPN2 this weekend.

By RJ Ochoa
NFL
Best bets for 2026 NFL Offensive Rookie of the YearBest bets for 2026 NFL Offensive Rookie of the Year
NFL

There are some good longer-shot options on offensive side of ball for the NFL’s Rookie of the Year.

By Bill Williamson
NFL
Brendan Sorsby is a rare chance to get a top QB cheap, and these teams should go inBrendan Sorsby is a rare chance to get a top QB cheap, and these teams should go in
NFL

This is a no-brainer for some NFL teams.

By James Dator
NFL
Fernando Mendoza has great respect for the Raiders that came before himFernando Mendoza has great respect for the Raiders that came before him
NFL

Fernando Mendoza has great respect for the Raiders that came before him

By RJ Ochoa