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Come Fan with UsThursday, June 25, 2026

Bills Vs. 49ers, Week 5: San Francisco nearly perfect in 45-3 blowout

The San Francisco 49ers cruised to their fourth victory of the season during Week 5, blowing out an overmatched Buffalo Bills team by a score of 45-3. The Niners dominated just about every facet of the game; Alex Smith threw for 304 yards and three scores, Michael Crabtree had his best game of the season with 113 yards and a touchdown, and Frank Gore had his way with 106 rushing yards on just 14 carries.

SB Nation’s 49ers blog, Niners Nation, was very pleased with their team’s performance on Sunday

This was as complete a victory as we have seen from the 49ers since...last week! But seriously, this two game stretch has seen the 49ers win by a combined score of 79-3. The Bills and Jets are obviously not among the better teams in the NFL at this point. At the same time, a domination like this is still a statement.

San Francisco will need to enjoy their victory briefly because the schedule is about to get a lot tougher. The New York Giants come to town in Week 6 for a matchup of last year's classic NFC Championship Game. That is followed by divisional home games with the Seahawks and Rams, with a road trip to take on the Cardinals sandwiched in between.

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