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Come Fan with UsSunday, June 21, 2026

LeSean McCoy injury update: Bills RB questionable vs Rams

LeSean McCoy suffered an injury in Buffalo’s final practice before heading to L.A.

NFL: Buffalo Bills at New England Patriots
NFL: Buffalo Bills at New England Patriots
Winslow Townson-USA TODAY Sports

Editor’s update: McCoy is expected to be active, per Ian Rapoport.

The Buffalo Bills are listing LeSean McCoy as questionable to face the L.A. Rams in Week 5. McCoy suffered a hand injury that he says will not keep him out this week, according to ESPN reporter Mike Rodak.

Practice injuries that occur just days before a game are scary scenarios for fantasy owners. It sounds like McCoy will be good to go, but this will be something to monitor over the weekend and leading up to when game day inactives come out.

In four games this season, McCoy has 297 rushing yards and three touchdowns to go with 17 receptions for 87 yards and another TD.

Fantasy Impact: Yahoo! ranks McCoy as the seventh-best running back in Week 5. He is going against a Rams defense allowing the 11th-fewest fantasy points to running backs over the past three weeks.

Even with McCoy’s injury against L.A.’s stout defense, keep him in your starting lineup this week.

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