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Come Fan with UsSunday, June 21, 2026

Brandon Jacobs, Joe Staley ACTIVE, Mario Manningham OUT for 49ers: Fantasy Implications

Jacobs and Staley will suit up for the San Francisco offense tonight, while Manningham is out. We break down the fantasy implications.

Ed Szczepanski-US PRESSWIRE

Brandon Jacobs will make his 49ers debut tonight against the Seattle Seahawks, after missing the first six weeks with a knee injury. Jacobs was signed in the offseason away from the New York Giants to act as a third-down and goal-line back, and he'll finally suit up for the first time in 2012 with a chance to do that. However, Mario Manningham will not be out there with him, as he is inactive with a shoulder injury. Manningham has played in all six games and has 24 catches for 258 yards and a touchdown.

Additionally, offensive tackle Joe Staley is active just days after suffering a head injury in Week 6 against the Giants.

Fantasy Take: It will be interesting to see how Jacobs' role takes away from Frank Gore and Kendall Hunter in fantasy, as the 49ers are the number one rushing offense in the NFL so far this season. Gore has four touchdowns on the year and Hunter has 5.5 yards per carry in relief duty, getting about half as many carries as Gore.

It would be hard to imagine that Jacobs himself is going to have a role worthy of a fantasy roster spot, but he could have major implications on the running game as a whole and decrease the value of Gore a bit in fantasy. It’s hard to not recommend starting Gore every week, but the Seahawks are ranked second in the NFL against the run and second in yards per carry allowed. This should be a very low-scoring game and even with Staley active, both offenses could struggle to score points.

For more fantasy info, check out the SB Nation Fantasy War Room 4-8:30pm ET Monday through Thursday and 8am to 1pm on Sunday. Check out SB Nation’s own Fantasy Football game, Pick 6!

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