Skip to main content
Come Fan with UsSunday, June 21, 2026

E.J. Manuel puts fantasy status into question after knee injury

Both starting quarterbacks went down in Thursday night’s matchup. E.J. Manuel wasn’t able to return. We break down the fantasy implications.

Ron Schwane-USA TODAY Sports

Bills rookie quarterback E.J. Manuel left early on Thursday night after suffering a knee injury in the third quarter. While scrambling for a 14-yard gain, Manuel took a hit to his right knee instead of stepping out of bounds. He didn’t return to the game after that point.

Manuel was seen jogging and riding an exercise bike on the sideline, so Buffalo could have simply kept him out as a precaution. Jeff Tuel, an undrafted rookie, took over under center after Manuel exited.

Fantasy impact: Manuel was 11-for-20 passing with 129 yards in his limited action. His No. 1 wideout Stevie Johnson also left with an injury, so the Bills offense was operating with issues from early on.

While Manuel shouldn’t be starting in anyone’s lineup right now, he’s shown upside over the first four weeks, and he become a viable fantasy option in the future. The Bills will likely update his status at some point on Friday.

More fantasy football news from SB Nation:

Get live advice daily in the Fantasy War Room

Today’s fantasy football player updates

Week 5 fantasy football rankings: QB | RB | WR | TE | D/ST

NFL
Best DFS picks for Patriots vs Texans in Divisional roundBest DFS picks for Patriots vs Texans in Divisional round
NFL

Chet Gresham takes us through his favorite picks for FanDuel’s Divisional round DFS matchup between the Patriots and Texans

By Chet Gresham
NFL
Best DFS picks for Bears vs Rams in Divisional roundBest DFS picks for Bears vs Rams in Divisional round
NFL

Chet Gresham takes us through his favorite picks for FanDuel’s Divisional round DFS matchup between the Bears and Rams

By Chet Gresham
NFL
Best DFS picks for Broncos vs Bills in Divisional roundBest DFS picks for Broncos vs Bills in Divisional round
NFL

Chet Gresham takes us through his favorite picks for FanDuel’s Divisional round DFS matchup between the Broncos and Bills

By Chet Gresham
NFL
Best DFS picks for Seahawks vs 49ers in Divisional roundBest DFS picks for Seahawks vs 49ers in Divisional round
NFL

Chet Gresham takes us through his favorite picks for FanDuel’s Divisional round DFS matchup between the 49ers and Seahawks

By Chet Gresham
NFL
Best DFS picks for Patriots-Chargers in Wild Card round matchupBest DFS picks for Patriots-Chargers in Wild Card round matchup
NFL

Chet Gresham takes us through his favorite picks for FanDuel’s Wild Card matchup between the Patriots and Chargers

By Chet Gresham
NFL
Best DFS picks for Jaguars-Bills in the Wild Card round matchupBest DFS picks for Jaguars-Bills in the Wild Card round matchup
NFL

Chet Gresham takes us through his favorite picks for FanDuel’s Wild Card DFS matchup between the Jaguars and Bills

By Chet Gresham