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Come Fan with UsMonday, June 22, 2026

NFL Odds, Week 5: Cam Newton Vs. Drew Brees, But Bet The Under

Check out lines and trends from the biggest games in Week 5. The Saints match up with Cam Newton and the Panthers in Week 5 action on Sunday, but if you’re expecting fireworks, you might not get them. All content comes courtesy of our odds partners at OddsShark.com.

So Cam Newton and Drew Brees - two of the three top-rated passers in the league - hook up Sunday and all the trends are pointing to an UNDER bet?

True, this is a different Carolina team hosting the Saints with the dynamic rookie under center. But betting UNDER the total has been money in the bank when the Saints visit the Panthers. As in, eight years, eight games, eight UNDERs. Add five recent games at New Orleans and the total run is 11-2 favoring the UNDER. It’s just one of many intriguing over/under trends in Week 5.

"It's one of those crazy streaks that you have to be aware of, even if your handicapping suggests something else will happen," said Mike Pickett of OddsShark.com. "Sometimes, you just have to hop on the trend bangwagon or at least get out of its way as it chugs along to the bank."

It's one of many key trends in Week 5 that focus on the total. A lopsided trend occurs in the Jets at Patriots battle where the Jets have been consistent OVER plays as an underdog (they get 9 points) and the Patriots have been consistent OVER plays as a favorite. [ Jets vs Patriots Matchup Stats ]

Does one trend cancel out the other or make it even stronger? The Jets have pledged to return to the ground game, which could chew up clock and make an UNDER more likely. But these Patriots can score in bunches and the total of 49 could be eclipsed by halftime.

See more Week 5 NFL trends below and full matchup data, searchable NFL databases, sortable ranking stats and live odds at SB Nation’s lines partner.

New Orleans -6.5 at Carolina +6.5 | Total 52.5 | Matchup 1:00 PM FOX

Past eight meetings here have all played UNDER

Under is 11-2 in the past 13 meetings overall

Saints just 2-7 ATS in their past 9 vs Panthers

Oakland +6 at Houston -6 | Total 48.5 | Matchup 1:00 PM CBS

Raiders 1-5 SU and ATS vs Texans

Houston is 16-3 favoring the OVER past 19 Oct games

Philadelphia -3 at Buffalo +3 | Total 50 1:00 PM | Matchup FOX

Eagles -6 in turnovers; Bills +7 in turnovers

OVER is 9-1-1 past 11 Eagle road games

Eagles 1-6 ATS past 7 as favorite

Kansas City +1.5 at Indianapolis -1.5 | Total 38.5 | Matchup 1:00 PM CBS

Indy is 10-1 SU and 9-2 ATS in their past 11 games with KC

Both teams head for their bye week in Week 6

Arizona +1.5 at Minnesota -1.5 | Total 45 1:00 PM FOX

Cardinals have lost 8 of 10 trips to the Metrodome

Cardinals OVER bet in October (15-3-1 past 19 games)

Tampa Bay +2 at San Francisco -2 | Total 41 4:05 PM FOX

UNDER is 12-3 past 15 meetings since 1984

Buccaneers are 9-2 SU in their last 11 games on the road

Bucs 1-8 SU past 9 trips to SF

NY Jets +9 at New England -9 | Total 49.5 4:15 PM CBS

Patriots 9-0 SU, 7-1-1 ATS past 9 at home in October

OVER is 9-1 past 10 when Jets are underdog

OVER is 17-3 in 20 games with the Pats as chalk

San Diego -4 at Denver + 4 | Total 47 4:15 PM CBS

Chargers OVER is 11-1 past 12 years before bye week

San Diego is 7-2-1 ATS past 10 vs Broncos

Green Bay -6 at Atlanta +6 | Total 53.5 8:20 PM NBC

Packers 10-3 ATS as a favorite

Falcons 3-1 ATS at home as underdog since 2008

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