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Come Fan with UsSunday, June 21, 2026

NFL Odds And Lines Week 17: 49ers Vs. Rams

The 49ers need a win in the final week to secure a first-round bye in the playoffs. Fortunately for them, they play the St. Louis Rams.

The San Francisco 49ers should have been using a season finale against the hapless St. Louis Rams to rest their starters. Instead, they need a win this week to earn a first-round bye and start the playoffs at home. For the Rams, the first pick in the 2012 NFL Draft is at stake. All they need is a Colts win and a loss in this game.

A Rams loss seems to be a widely predicted outcome this week. San Francisco opened as 10-point favorites. The line has since moved to 12 points for some odds makers. St. Louis has been among the worst teams against the spread with just a 2-12-1 mark this season. The 49ers are the opposite, owning a 11-3-1 record against the spread.

The over/under on this game is set at 36 and a half points. St. Louis has the league's worst offense, averaging less than 12 points per game and coming off a shutout against the Steelers last week. San Francisco won't likely need many points to win this one.

For more odds and lines from Week 17, check out Odds Shark. For more on the 49ers, head over to Niners Nation. Check out Turf Show Times for more on the Rams.

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