Skip to main content
Come Fan with UsSaturday, June 20, 2026

E.J. Manuel injury: Bills quarterback leaves after hit to knee

A second quarterback has left Thursday’s game with a knee injury.

Andrew Weber-USA TODAY Sports
James Dator
James Dator has been covering a wide range of sports for SB Nation for over a decade, with a special focus on the NFL.

Buffalo Bills quarterback E.J. Manuel left Thursday's game with a knee injury after taking a hit in the third quarter against the Cleveland Browns.

Manuel scrambled for a first down and was hit as he attempted to run out of bounds. He screamed in pain before falling to the ground. Trainers wasted no time surrounding him before he was brought to the sideline for evaluation. Manuel left the bench and attempted to walk off the injury, but was later seen wearing flip-flops in the trainer’s room.

Jeff Tuel will finish Thursday's game in Manuel's absence. He was set to start the first game of the season before Manuel recovered quick enough to take the job.

It was the second knee injury of Thursday's game. Early in the first quarter, Browns quarterback Brian Hoyer was hit on a scramble and may have suffered torn ligaments.

More from SB Nation NFL

Bucs officially dump Josh Freeman

Week 5 picks: Rise of the underdogs | Watchability Index

In which the Eagles get drunk and give up 2,400 rushing yards | Breaking Madden

The Notebook: What makes Russell Wilson so good

Eugene Monroe traded to Ravens | Steelers get Levi Brown

NFL power rankings: Saints go marchin’

See More:

More in NFL

NFL
WNFC championship game airing Sunday, June 21st from Ford Center in FriscoWNFC championship game airing Sunday, June 21st from Ford Center in Frisco
NFL

The Women’s National Football Conference Championship will air on ESPN2 this weekend.

By RJ Ochoa
From SBNationExternal Link
Which fictional quarterback would you have lead your team?Which fictional quarterback would you have lead your team?
From SBNationExternal Link
By James Dator
NFL
Best bets for 2026 NFL Offensive Rookie of the YearBest bets for 2026 NFL Offensive Rookie of the Year
NFL

There are some good longer-shot options on offensive side of ball for the NFL’s Rookie of the Year.

By Bill Williamson
NFL
Brendan Sorsby is a rare chance to get a top QB cheap, and these teams should go inBrendan Sorsby is a rare chance to get a top QB cheap, and these teams should go in
NFL

This is a no-brainer for some NFL teams.

By James Dator
NFL
Fernando Mendoza has great respect for the Raiders that came before himFernando Mendoza has great respect for the Raiders that came before him
NFL

Fernando Mendoza has great respect for the Raiders that came before him

By RJ Ochoa
NFL
Brendan Sorsby intends to enter NFL Supplemental Draft, per reportsBrendan Sorsby intends to enter NFL Supplemental Draft, per reports
NFL

Texas Tech quarterback Brendan Sorsby is entering the NFL Supplemental Draft, per reports

By Mark Schofield