Skip to main content
Come Fan with UsSunday, June 21, 2026

Fantasy football waiver wire advice: Karlos Williams has huge game in injury return

The rookie running back scored two touchdowns Sunday. We break down the fantasy implications.

Timothy T. Ludwig-USA TODAY Sports

In his first game since Week 4 because of a concussion, Buffalo Bills rookie running back Karlos Williams had a huge game Sunday. The rookie scored his fifth and sixth career touchdowns in Buffalo’s 33-17 win over the Miami Dolphins.

Williams didn’t see heavy usage early in the game, serving primarily as the change-of-pace back for starter LeSean McCoy. The starter suffered a second-half shoulder injury, though, giving way for Williams to produce. He had 110 rushing yards and two scores on nine carries in the game, good for a 5.4 yards-per-carry average.

Fantasy impact: McCoy insisted after the game that his shoulder injury wasn’t serious and said he’d play in Week 10, a Thursday game in which the Bills play the New York Jets. If so, Williams will be little beyond a change-of-pace back again, but even in that role, he’s shown enough that he’d be worth a look as a mid-range flex.

If McCoy underrates his injury and he can’t play Thursday, Williams -- who has scored at least one touchdown in each of his first five career games, the seventh ever to do so -- would become a fine fantasy starter, ranked in the mid-teens at the position. Either way, he should be owned in all leagues, and not just as a McCoy handcuff. Williams has value in his own right.

NFL
Best fantasy football waiver wire pickups for Week 18Best fantasy football waiver wire pickups for Week 18
NFL

Tyler Shough, Bill Croskey-Merritt, and Parker Washington highlight the top waiver wire targets entering Week 18.

By Nick Simon
NFL
Tyler Allgeier start or sit: Week 17 fantasy football adviceTyler Allgeier start or sit: Week 17 fantasy football advice
NFL

We break down the fantasy football outlook of Tyler Allgeier ahead of the Falcons’ Week 17 matchup vs. the Rams.

By Nick Simon
NFL
Blake Corum start or sit: Week 17 fantasy football adviceBlake Corum start or sit: Week 17 fantasy football advice
NFL

We break down the fantasy football outlook of Blake Corum ahead of the Rams’ Week 17 matchup vs. the Falcons.

By Nick Simon
NFL
Isaiah Davis start or sit: Week 17 fantasy football adviceIsaiah Davis start or sit: Week 17 fantasy football advice
NFL

We break down the fantasy football outlook of Isaiah Davis ahead of the Jets’ Week 17 matchup vs. the Patriots.

By Nick Simon
NFL
Rhamondre Stevenson start or sit: Week 17 fantasy football adviceRhamondre Stevenson start or sit: Week 17 fantasy football advice
NFL

We break down the fantasy football outlook of Rhamondre Stevenson ahead of the Patriots’ Week 17 matchup vs. the Jets.

By Nick Simon
NFL
Chris Rodriguez Jr. start or sit: Week 17 fantasy football adviceChris Rodriguez Jr. start or sit: Week 17 fantasy football advice
NFL

We break down the fantasy football outlook of Chris Rodriguez Jr. ahead of the Commanders’ Week 17 matchup vs. the Cowboys.

By Nick Simon